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KMID : 0043320100330101561
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Archives of Pharmacal Research
2010 Volume.33 No. 10 p.1561 ~ p.1564
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Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity
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Choi Yun-Hyeok
Hon Seong-Su
Shin Yu-Su
Hwang Bang-Yeon
Park So-Young
Lee Dong-Ho
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Abstract
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Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED50 values of 33.7 and 27.8 μM, respectively. In addition, a new coumestan, 2-(α,α-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques.
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KEYWORD
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Pueraria lobata, Fabaceae, 2-(α, α-dimethylallyl)coumestrol, Isoflavone, Beta-amyloid
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